More Information
Selected Publications:
Yang, Z., Gurvich, V.J., Gupta, M.L., Jr., Mivechi, N.F., Ko, L. (2019). Oncoprotein GT198 is a direct target of taxol. bioRxiv 675579; doi: https://doi.org/10.1101/675579. [go to article]
Proudfoot, K.G., 1Anderson, S.J., 1Dave, S., Bunning, A.R., Sinha Roy, P., Bera, A., Gupta, M.L., Jr. (2019). Checkpoint proteins Bub1 and Bub3 delay anaphase onset in response to low tension independent of microtubule-kinetochore detachment. Cell Reports; in press. [1equal contribution]
Dave, S., Anderson, S.J., Sinha Roy, P., Nsamba, E.T., Bunning, A.R., Fukuda, Y., Gupta, M.L., Jr. (2018). Discrete regions of the kinesin-8 Kip3 tail differentially mediate astral microtubule stability and spindle disassembly. Molecular Biology of the Cell 29(15):1866-77. PMID: 29874146
Feng, R., Sang, Q., Kuang, Y., Sun, X., Yan, Z., Zhang, S., Shi, J., Tian, G., Luchniak, A., Fukuda, Y., Li, B., Yu, M., Chen, J., Xu, Y., Guo, L., Qu, R., Wang, X., Sun, Z., Liu, M., Shi, H., Wang, H., Feng, Y., Shao, R., Chai, R., Li, Q., Xing, Q., Zhang, R., Nogales, E., Jin, L., He, L., Gupta, M.L., Jr., Cowan, N.J., Wang, L. (2016). Mutations in TUBB8 and Human Oocyte Meiotic Arrest. New England Journal of Medicine 374(3):223-32. PMCID: PMC4767273
Fukuda, Y., Luchniak, A., Murphy, E.R., Gupta, M.L., Jr. (2014). Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8. Current Biology 24(16):1826-35. PMID: 25088560
Rizk, R.S., DiScipio, K.A., Proudfoot, K.G., Gupta, M.L., Jr. (2014). The kinesin-8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization. Journal of Cell Biology 204(6):965-75. PMID: 24616221
1Cederquist, G.Y., 1Luchniak, A, Tischfield, M.A., Peeva, M, Song, Y, Menezes, M.P., Chan, W., Andrews, C., Chew, S., Jamieson, R.V., Gomes, L., Flaherty, M., Grant, P.E., *Gupta, M.L., Jr., *Engle, E.C. (2012). An inherited TUBB2B mutation alters a kinesin binding site and causes polymicrogyria, CFEOM, and axon dysinnervation. Human Molecular Genetics 21(26):5484-99. [1equal contribution, *co-corresponding authors] PMID: 23001566
1Entwistle, R.A., 1Rizk, R.S., Cheng, D.M., Lushington, G.H., Himes, R.H., Gupta, M.L., Jr. (2012). Differentiating between models of Epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem 7(9):1580-6. [1equal contribution] PMID: 22807375
Tischfield, M.A., Baris, H.N., Wu, C., Rudolph, G., Van Maldergem, L., He, W., Chan, W.-M., Andrews, C., Demer, J.L., Robertson, R.L., Mackey, D.A., Ruddle, J.B., Bird, T.D., Gottlob, I., Pieh, C., Traboulsi, E.I., Pomeroy, S.L., Hunter, D.G., Soul, J.S., Newlin, A., Sabol, L.J., Doherty, E.J., de Uzcategui, C.E., De Uzcategui, N., Collins, M.L., Sener, E.C., Wabbels, B., Hellebrand, H., Meitinger, T., de Berandinis, T., Magli, A., Schiavi, C., Pastore-Trossello, M., Koc, F., Wong, A.M., Levin, A.V., Geraghty, M.T., Descartes, M., Flaherty, M.P., Jamieson, R., V., Moller, H.U., Meuthen, I., Callen, D.F., Kerwin, J., Lindsay, S., Meindl, A., *Gupta, M.L., Jr., Pellman, D., and *Engle, E.C. (2010). Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell 140(1):74-87. [*co-corresponding authors] PMID: 20074521
Gupta, M.L., Jr., Carvalho, P., Roof, D.M., Pellman, D. (2006). Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nature Cell Biology 8:913-23.
Gupta, M.L., Jr., Bode, C.J., Georg, G.I., Himes, R.H. (2003). Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin. Proceedings of the National Academy of Sciences, USA 100:6394-7.