Melha Mellata

Assistant Professor

Teaching

MICRO 517: Gut Microbiota: Implications in Health & Diseases (3 Credits-Fall)

Recent Publications

  1. Stromberg ZR., A. Van Goor, GAJ. Redweik, MJ. Wymore Brand, MJ. Wannemuehler, and M. Mellata. 2018 Pathogenic and non-pathogenic Escherichia coli colonization and host inflammatory response in a defined microbiota mouse model. Dis. Mod. Mech. dmm.035063 doi: 10.1242/dmm.035063 P.
  2. Stromberg ZR, A Van Goor, GAJ. Redweik, and M. Mellata. 2018 Characterization of Spleen Transcriptome and Immunity Against Avian Colibacillosis After Immunization with Recombinant Attenuated Salmonella Vaccine Strains. Front. Vet. Sci. doi: 10.3389/fvets.2018.00198.
  3. Stromberg ZR, GAJ. Redweik, and M Mellata. 2018 Detection and Cell-Based Methods for Evaluating Non-O157 Shiga Toxin-Producing Escherichia coli from Cattle. Foodborne Pathog Dis 15(3):119-131. (Invited-published in a special edition: 15thanniversary of the journal).
  4. Maddux JT, ZR. Stromberg, R. Curtiss 3rd, M. Mellata. 2017 Evaluation of Recombinant Attenuated Salmonella Vaccine Strains for Broad Protection against Extraintestinal Pathogenic Escherichia coli. Front Immuno 8:1280. doi: 10.3389/fimmu.2017.01280.
  5. Van Goor A., ZR. Stromberg, and M. Mellata. 2017 A Recombinant Multi-Antigen Vaccine with Broad Protection Potential against Avian Pathogenic Escherichia coli. Vaccine PlosOne, 12(8): e0183929.
  6. Stromberg ZR, JR. Johnson, JM. Fairbrother, A. Van Goor, R. Curtiss 3rd, and M. Mellata. 2017. Evaluation of Escherichia coli isolates from healthy chickens to determine their potential risk to poultry and human health. PlosOne 12(7): e0180599.
  7. Mellata M., JR. Johnson, and R. Curtiss. 2017 Escherichia coli Isolates from Commercial Chicken Meat and Eggs Cause Sepsis, Meningitis, and Urinary Tract Infection in Rodent Models of Human Infection. Zoonoses and public Health 2017; 00:1–11.
  8. Mellata M., NM. Mitchell, F. Schödel, R. Curtiss 3rd, GB. Pier. 2016. Novel vaccine antigen combinations elicit protective immune responses against Escherichia coli sepsis. Vaccine 34 (5): 656-662

Visit the link for more details on publications

https://scholar.google.com/citations?user=ZPEtrpcAAAAJ&hl=en

Patents Granted

  1. Curtiss, R. III, M. Mellata, B. Zekarias, Z. Shi, C. Branger, and K. Roland. Recombinant bacterium capable of eliciting an immune response against enteric pathogens. Salmonella vaccine against bacterial enteric pathogens. U.S. Patent No. 8,465,755B2 filled 10/06/08 (granted 06/18/13).  https://www.google.com/patents/US8465755
  2. Mellata M. Recombinant Bacterium Comprising a Toxin/Antitoxin System as a Vaccine Vector.” U.S. Provisional Application No. 61/417,046 and No 61/417,030, filed 11/24/2010, PCT/US2011/061896,     filed   11/24/2011                       (granted         12/01/2015).  https://www.google.ch/patents/WO2012087483A1?cl=en
Area of Expertise: 
Microbiology
Immunology
host-pathogen interactions. antibiotic resistance
Education: 
PhD, University of Montreal
Post doc, Washington University
Post doc, Biodesign Institute, Arizona State University
Contact
+1 515 294 9220
3346 Food Science Building
Ames
IA
50011-1061